ALCALOIDES DE LA VINCA PDF

Se presenta un caso de hiporreflexia vesical como primera manifestación de neurotoxicidad, debida a la administración de los alcaloides de la Vinca; estas. Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus. File:BIOSÍNTESIS DE LOS ALCALOIDES DE LA From Wikimedia Click on a date/time to view the file as it appeared at that time.

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Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant.

File:BIOSÍNTESIS DE LOS ALCALOIDES DE LA VINCA.png

They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects. They have been used to treat diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are also important for being cancer fighters. There are four major vinca alkaloids in clinical use: Vinflunine is also a new synthetic vinca alkaloid, which has been approved in Europe for the alcalooides of second-line transitional cell carcinoma of the urothelium is being developed for other malignancies.

Vinca alkaloids are the second-most-used class of cancer drugs and will stay among the original cancer therapies. Different alxaloides and studies for new vinca alkaloid applications will be carried out in this regard.

Vinca alkaloids are a material of a class of organic compounds made up of carbon, hydrogen, nitrogen and oxygen that is often derived from plants is named alkaloid.

Although, the name represents alkali like some do not exhibit alkaline properties. Many alkaloids with having poisonous characteristics have physiological effects too that make them useful as medicines.

Vinca alkaloids are obtained from the Madagascar periwinkle plant. They are naturally occurring vinac semi synthetic nitrogenous bases extracted from the pink periwinkle plant Catharanthus roseus G. Don[ 3 ] [ Figure 1 ]. Vinca alkaloids were found out in the ‘s by Canadian scientists, Robert Alcqloides and Charles Beer for the first time. Medicinal applications of this plant lead to the monitoring of these compounds for their hypoglycemic activity, which is of little importance compared to their cytotoxic effects.

alcaloides de la vinca – English Translation – Word Magic Spanish-English Dictionary

Nevertheless, the vinca alkaloids are so important for being cancer fighters. The flowers of Catharanthus roseus G. Vinca rosea an evergreen shrub, it grows to a height of 1 m with a spread of 1 m.

The stem is short, erect and branching; the leaves are glossy green, oval, 5 cm long and opposite acuminate; the flowers are soft pink, tinged with red, 5 petal, open, tubular and 4 cm across, appearing in spring and autumn three colors: The main mechanisms of vince alakaloid cytotoxicity is due to their interactions with tubulin and disruption of microtubule function, particularly of microtubules comprising the mitotic spindle apparatus, directly causing metaphase arrest.

Many of the effects that do not include microtubule interruption happen only after treatment of cells with clinically irrelevant doses of the vinca alkaloids. Nevertheless, the vinca alkaloids and other antimicrotubule agents also have an effect on both non-malignant and malignant cells in the non-mitotic cell cycle, because microtubules are involved in many non-mitotic functions.

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Existing evidence maintains the existence of two vinca alkaloid binding sites per mole of tubulin dimer. The vinca alkaloids and other microtubule disrupting agents have power to inhibit malignant angiogenesis in vitro. For example, VBL with concentrations range from 0. In combination with antibodies against vascular endothelial growth factor, low doses of VBL increased antitumor response considerably, even in tumors resistant to direct cytotoxic effects of the drug.

VCR and related compounds produce destabilization of microtubules by binding to tubulin and blocking the polymerization. The vinca alkaloids have been generally included in combination chemotherapy regimens for medicinal therapies.

They do not have cross-resistance with drugs that alkylate deoxyribonucleic acid DNA and have a different mechanism of action. Side-effects of VBL consist of toxicity to white blood cells, nausea, vomiting, constipation, dyspnea, chest or tumor pain, wheezing and fever. It is also rarely associated with antidiuretic hormone secretion. It has significant antitumor activity in patients with breast cancer and can be affected on bone tumor cells, osteosarcoma.

In addition, VRL decreases the stability of lipid bilayer membranes. In the United States, VRL has been approved for the initial treatment of patients with advanced lung cancer. Decreasing resistance to infection, bruising or bleeding, anemia, constipation, diarrhea, nausea, numbness or tingling in the hands and feet, fatigue also called peripheral neuropathy and inflammation at the injection site.

Less common side-effects include hair loss and allergic reaction.

VCR has been approved to treat acute leukemia, rhabdomyosarcoma, neuroblastoma, Wilm’s vinva, Hodgkin’s disease and other lymphomas. Another characteristic of VCR that dd been reported is treating several non-malignant hematologic disorders such as refractory autoimmune thrombocytopenia, hemolytic alca,oides syndrome and thrombotic thrombocytopenia purpura.

VCR’s most common side-effects are: Peripheral neuropathy, suppression of bone marrow activity, constipation, nervous system toxicity, nausea and vomiting. Antineoplastic activity of VDS has been reported in acute lymphocytic leukemia, blast crisis of chronic myeloid leukemia, malignant melanoma, pediatric solid tumors and metastatic renal, breast, esophageal and colorectal carcinomas. This compound has been used in Europe for the treatment of second-line transitional cell carcinoma of the urothelium TCCUis being developed for other malignancies.

It has been applied for clinical development in the wide spectrum of solid tumors. Clinically, important activity has been seen mainly in the treatment of transitional cell alcaloires of the urothelial tract, non-small cell lung cancer and carcinoma of the breast.

Vinflunine is has been also assessed in patients with TCCU and first-line advanced breast cancer. Although, the vinca alkaloids are quite similar from a structural position, their toxicologic profiles are different extensively. All vinca alkaloids make a characteristic peripheral neurotoxicity, but VCR has most potential in this case.

The neurotoxicity is mostly distinguished by a peripheral, symmetric varied sensory-motor vica autonomic polyneuropathy. The uptake of VCR into the brain is low and central nervous system effects, such as confusion, mental status changes, depression, hallucinations, agitation, insomnia, seizures, coma, syndrome inappropriate secretion of antidiuretic hormone and visual disturbances are infrequent.

Laryngeal paralysis has also been informed. The only known effective interference for vinca alkaloid neurotoxicity is discontinuing treatment or decrease of the dose or frequency of drug administration.

Although a number of antidotes, including thiamine, vitamin B 12folinic acid, pyridoxine and neuroactive agents, have been applied, these treatments have not been obviously shown to be effective. Thrombocytopenia alcaloiees anemia vijca have been seen less. In addition, VCR is related with hematologic toxicity rarely, severe myelosuppression has been monitored in situations resulting in zlcaloides increased drug exposure and hepatic deficiency. Gastrointestinal toxicities, aside from those caused by autonomic dysfunction, may be observed with using vinca alkaloids.

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Nausea, vomiting and diarrhea may also occurred. The vinca alkaloids are effective vesicants and may lead to significant tissue damage too. These alcaooides should not be used by a patient who is pregnant, has planning for pregnancy or has breast-feeding as it may cause birth defects.

Patients should not receive any vaccinations while taking this medication. VCR may cause weakness of immunity system and ve lead to an illness.

Vinca alkaloids have been generally included in combination chemotherapy regimens for medicinal therapies. They do not have cross-resistance with drugs that alkylate DNA and have a different mechanism of action. They have been used to treat diabetes, high blood pressure and have been used as disinfectants and anti-cancer. The vinca alkaloids have cytotoxic effects that can arrest the division of cells and causes cell alcaloiddes. Vinflunine is also a new synthetic vinca alkaloid, which has been approved in Europe for the treatment of second-line TCCU, is being developed for other malignancies.

Overall, vinca alkaloids have the second most-used class of cancer drugs and will stay among the original cancer therapies. National Center for Biotechnology InformationU. Int J Prev Med.

Author information Article notes Copyright and License information Disclaimer. Received Mar 14; Accepted May This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC. Abstract Vinca alkaloids are alcaloidees subset of drugs obtained from the Madagascar periwinkle plant.

Madagascar alcalojdes, vinblastine, vinca alkaloids, vincristine, vindesine, vinflunine, dde. Open in a separate window. Footnotes Source of Support: Nil Conflict of Interest: Alkaloid substances in plants, information on vinca, ergot and ephedra alkaloid compounds.

Jun 7, [Cited on Sep 23]. BC Decker Inc; Crit Rev Oncol Hematol. A new microtubule inhibitor agent. Drug safety evaluation of this novel synthetic vinca alkaloid. Expert Opin Drug Saf. Interactions of the catharanthus Vinca alkaloids with tubulin and microtubules. Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics.

Annu Rev Alclaoides Dev Biol. Correia JJ, Lobert S. Physiochemical aspects of tubulin-interacting antimitotic drugs. Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles.

Implications for the role of microtubule dynamics in mitosis. Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine. Antiangiogenesis is produced by nontoxic doses of vinblastine.

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: Paclitaxel taxol N Engl J Med. The comparative clinical pharmacology of vincristine and vindesine: