Owing to pseudoexfoliation glaucoma’s prevalence and severity, gonioscopy should be performed to assess for pigment deposition and a Sampaolesi’s line. Sampaolesi line is a sign which may be observed during a clinical eye examination. During gonioscopy if an abundance of brown pigment is seen at or anterior. The Glaucomas. Volume II – Open Angle Glaucoma and Angle Closure Glaucoma. Authors; (view affiliations). Roberto Sampaolesi; Juan Roberto Sampaolesi.

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Methods for decreasing pigment particles in the anterior chamber in exfoliation syndrome and pigment dispersion syndrome.

Three zones are present on the anterior lens capsule in exfoliation syndrome. Note the clear area between the central disc and the peripheral zone.

Iris sphincter transillumination defects in exfoliation syndrome result from the dispersion of pigment into the anterior chamber. The release of pigment into the anterior chamber is common and profuse after pupillary dilation in patients with exfoliation syndrome. Unrecognized pressure spikes may vlaucoma glaucomatous damage, particularly in patients whose disease is moderate to severe.

Sampaolesi line – Wikipedia

We have seen a patient with exfoliative glaucoma who suffered a central retinal vein occlusion and an IOP spike to 55 mm Hg after pupillary dilation. Drug Therapy In sampaooesi with exfoliation syndrome, inhibiting the release of pigment should slow glaucomatous progression by blocking the mechanism most responsible for elevated IOP in these eyes. Theoretically, miotics should be the first line of treatment. Decreasing pupillary movement may reduce iridolenticular friction and thus avert the liberation of iris pigment, slow the progression of trabecular blockage, and perhaps allow the meshwork to clear.

Sampaolesi line

After undergoing treatment for sufficiently long periods with miotic therapy, we observed an early pigment reversal sign, 10 which indicates that pigment has cleared from the trabecular meshwork. The mechanism underlying IOP elevation in patients with pigment dispersion syndrome and pigmentary glaucoma is analogous to that in exfoliation syndrome.

In pigment dispersion syndrome and pigmentary glaucoma, the iris insertion is typically posterior, sampaolssi the peripheral iris configuration tends to be concave.

Iridozonular contact during accommodation as well as during normal pupillary constriction and dilation disrupts the iris pigment epithelium and results gpaucoma the deposition of pigmentary granules throughout the anterior segment. Midperipheral iris transillumination defects occur in pigment dispersion syndrome. Hyperpigmentation of the trabecular meshwork occurs in patients with pigment dispersion syndrome. Patients with pigment dispersion syndrome or pigmentary glaucoma can also experience sudden IOP spikes after pupillary dilation.


The examination and glajcoma of these patients is similar to that described earlier for exfoliation syndrome.

Vibration-induced increases in trabecular pigmentation have also been reported in eampaolesi drillers. In practice, pilocarpine completely stops the exercise-induced release of pigment and elevation of IOP, 12,13,18,19 whereas dapiprazole has a lesser effect 20 and iridotomy provides incomplete inhibition. Pilocarpine drops are poorly tolerated, however, because of accommodative spasm and induced myopia in younger patients.

Pilocarpine Ocuserts were ideal for patients with pigment dispersion syndrome or pigmentary glaucoma, because these drugs were well tolerated and effective at both lowering IOP and inhibiting pigmentary release. Unfortunately, they are no longer manufactured, which has created a serious problem for our younger patients.

Wang et al 25 conducted a review of 23 patients with pigment dispersion syndrome and elevated IOP who had no or only mild glaucomatous damage and who had undergone laser iridotomy. The investigators found no significant difference in the long-term reduction of IOP in the lasered eyes compared with the medically treated fellow eyes. The latter had mostly received treatment with pilocarpine Ocuserts and latanoprost. Now that Ocuserts are no longer available, the use of laser iridotomy will probably increase.

By preventing the liberation of pigment from the iris, laser iridotomy should allow the trabecular meshwork to sampaolezi itself and avoid glauucoma pigmentary deposition.

Candidates for the procedure, therefore, are in the pigment-liberation stage. In such individuals, pupillary dilation likely will lead to the release of pigment into the anterior chamber.

Patients with uncontrolled glaucoma are poor candidates for laser iridotomy, since clearing of the meshwork and the subsequent IOP reduction requires a long sqmpaolesi after the laser iridotomy.

As a rule of thumb, we restrict iridotomy to patients under 45 years of age who have elevated Sampaolesl, demonstrate no early glaucomatous damage, and experience a release of pigment upon pharmacologic dilation or spontaneously after exercise. Because not all patients with pigment dispersion syndrome develop elevated IOP, and because the iridotomy procedure itself results in a significant release of pigment, we do not currently advocate treating normotensive eyes.

Reducing the release of pigment may slow the progression of these diseases and may even lead to a clearing of the trabecular meshwork. He stated that he holds no financial interest in the products mentioned herein.

Ritch may be reached at ; ritchmd earthlink. Shihadeh may be reached at ; wisam97 yahoo. Preclinical diagnosis of pseudoexfoliation syndrome. Aggarwal JL, Beveridge B. Liberation of iris pigment in the anterior chamber. Pigment liberation test in open-angle glaucoma.

Prince AM, Ritch R. Clinical signs of the pseudoexfoliation syndrome. Pseudoexfoliation of the lens capsule. The cyclopentolate provocative test in suspected or untreated open-angle glaucoma: The significance of pigment for the result of the cyclopentolate provocative test in suspected or untreated open-angle glaucoma.

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Delayed intraocular pressure elevation after pupillary dilation in exfoliation syndrome ARVO abstract. Invest Ophthalmol Vis Sci. Mydriasis-induced pigment liberation in the anterior chamber associated with acute rise in intraocular pressure in open-angle glaucoma. Exercise-induced increase of sampaoleis pressure in the pigmentary dispersion syndrome. Effects of jogging exercise on patients with the pigment dispersion syndrome and pigmentary glaucoma.

The effects of exercise on intraocular asmpaolesi in pigmentary glaucoma patients. Exercise and iris concavity smapaolesi healthy eyes. Exercise and reversed pupillary block in pigmentary glaucoma. Ocular sequelae of pneumatic drills. Improvement of pigmentary glaucoma and healing of transillumination defects with miotic therapy.

Inhibition of exercise-induced pigment dispersion in a patient with the pigment dispersion syndrome. The effectiveness of dapiprazole in preventing exercise-induced IOP increase in patients with pigmentary dispersion syndrome. Incomplete elimination of exercise-induced pigment dispersion by laser iridotomy in pigment dispersion syndrome. Iridolenticular sapaolesi decreases following laser iridotomy for pigment dispersion syndrome.

Accommodation and iridotomy in the pigment dispersion syndrome. Quantification of aqueous melanin granules in primary pigment dispersion syndrome. Long-term outcome of argon laser iridotomy in pigment dispersion syndrome. Kala Glaicoma announced that it will be presenting at the Spotlight on dry eye session at the Ophthalmology Innovation Summit at the American Society of Cataract and Re…. RegeneRx Biopharmaceuticals announced the outcome of discussions between its U.

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