Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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The sign of Leser-Trelat in a case of adenocarcinoma of the lung. There does not appear to be an increased frequency of a specific histopathological variation of seborrheic keratoses that correlates with the sign of Leser-Trelat.

Sign of Leser-Trélat

Indian J Dermatol Venereol Leprol ; History and Physical As previously mentioned, seborrheic keratoses are a nearly ubiquitous, benign skin lesion in patients greater than 40 years of age. Lesions tend to resolve once the underlying cancer is treated. Eruptive seborrheic keratoses have been reported in numerous other clinical scenarios including in patients with erythroderma, pregnant patients, HIV-infected patients, and transplant patients.

However, the sudden eruption of seborrhoeic keratoses in young patients points to a paraneoplastic process and should prompt an investigation for a hidden cancer.


Oxford University Press US. Malignant involvement of the skin and the genodermatoses. Author Information Authors Courtney N.

Retrieved from ” https: Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. Aldrich-Mees’ lines Beau’s lines Muehrcke’s lines Terry’s nails.

In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic. Multiple sivn seborrheic keratoses on the a face and neck, b breast, and c back Click here to view. The sign of Leser-Trelat. Create a free personal account to access your subscriptions, sign up for alerts, and more.

Leser–Trélat sign

Images in clinical medicine. Malignant acanthosis nigricans, tripe palms and the sign of Leser-Trelat, a hint to the diagnosis of early stage ovarian cancer: Create a free personal account to download free article PDFs, sign up for alerts, and more.

Two months before, she had noticed the sudden appearance of many “warts” on her face and neck. Register lesfr email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts. Purchase access Subscribe now.


Poole S, Fenske NA.

Andrews’ diseases trelxt the skin: Although the back is the most common location, additional sites may include the extremities, face, neck, and abdomen. It may possibly be due to the same unknown factors that induce malignant acanthosis nigricans.

Curth’s postulates are a well-known set of clinical criteria that were created to help evaluate the temporal relationship between an underlying malignancy and a specific dermatological condition.

Sign of Leser-Trélat | DermNet NZ

Patients will often complain of pruritus associated with these lesions. Bernett ; George J. Paraneoplastic dermatological manifestation of gastrointestinal malignancies. Epub May Purchase access Subscribe to the journal.

Cutaneous manifestations of internal malignancy. They appear as brown warty nodules with a stuck-on appearance. As previously mentioned, seborrheic keratoses are a nearly ubiquitous, benign skin lesion leer patients greater than 40 years of age.